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      Acetaminophen for Injection

      Intravenous Acetaminophen for Acute Pain Management 

      As part of a multimodal analgesia strategy, B. Braun’s Acetaminophen for Injection delivers pain relief in 3 convenient sizes for both adult and pediatric patients—helping reduce opioid use and shorten hospital stays1,2.

      Opioid Crisis in Canada

      Why Opioid-Sparing Medications Matter 

      • 0

        Opioid poisoning hospitalizations (2016-2021, excluding Quebec)3

      • 0%

        Of Canadians aged 15+ used opioids in the past year (2018)3

      • $ 0B

        Estimated cost of opioid use to the Canadian economy (2017)3

      What is Intravenous Acetaminophen?

      Intravenous Acetaminophen (commonly known as IVA) is a parenteral formulation designed for hospital-based pain management when oral or rectal administration is not suitable. IVA offers faster onset, higher bioavailability, and more predictable absorption, making it a valuable tool in curbing the opioid crisis 4,5.

      Frequently Asked Questions (FAQs)

      Yes. Intravenous acetaminophen is often used alongside opioids as part of a multimodal pain management strategy. This combination can enhance pain relief, reduce the need for higher opioid doses, and help minimize opioid-related side effects 6,8.

      Intravenous acetaminophen (IVA) is not necessarily stronger than oral acetaminophen (OA) but offers certain advantages in clinical settings: 

      • Faster analgesic onset 4
      • Reduced postoperative opioid use 1
      • Shorter hospital stays 2

       

      Learn More

      The maximum dose of intravenous acetaminophen depends on both the patient’s age and weight. 

      • Pediatrics (< 2 years of age): The safety and efficacy have not been established.
      • Children (2-12 years of age): 12.5 mg/kg every 4 hours or 15 mg/kg every 6 hours, up to 75 mg/kg in 24 hours.
      • Adults and adolescents ≤50 kg: 12.5 mg/kg every 4 hours or 15 mg/kg every 6 hours, with a maximum of 75 mg/kg (up to 3,750 mg) in 24 hours.
      • Adults and adolescents ≥50 kg (no additional factor for hepatotoxicity): 650 mg every 4 hours or 1,000 mg every 6 hours, with a maximum of 4,000 mg in 24 hours.

       

      See Dosing Recommendations Table

      For B. Braun's Acetaminophen for Injection, please administer the contents of the container intravenously over 15 minutes.

      Acetaminophen Injection is contraindicated in 7:

      • Patients who have previously demonstrated hypersensitivity to acetaminophen, to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container
      • Patients with severe hepatic impairment or severe active liver disease

       

      Acetaminophen: The First-Step Relief in Multimodal Analgesia
      The WHO three-step analgesic ladder

      The World Health Organization (WHO) recommends starting pain management with non-opioids like acetaminophen before escalating to opioids. As part of a multimodal approach, B. Braun’s acetaminophen for injection provides rapid-onset pain relief while helping reduce opioid use 6. 

      “Clinicians should maximize use of nonopioid pharmacologic (e.g., acetaminophen) and nonpharmacologic therapies as appropriate.”

      Dowell et al. 2022, CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022

      Intravenous or Oral Acetaminophen?

      Choose the Faster, Safer Option

      Intravenous Acetaminophen (IVA) is clinically shown to deliver faster pain relief than oral acetaminophen (OA), highlighting IVA’s clear advantage in time-sensitive clinical settings4:

       

      • Analgesia onset:
        • IVA (15-min infusion): 5 minutes
        • OA: 11 minutes
      • Meaningful pain relief:
        • IVA (15-min infusion): 8 minutes
        • Oral: 37 minutes    
      Moller et al. 2005
      Marcotte et al. 2020

      Intravenous Acetaminophen (IV) is clinically shown to reduce perioperative opioid use compared to oral acetaminophen (OA)1:

       

      • Total postoperative opioid use (72 hours):
        • IVA: 68.8 oral morphine equivalents (OME)
        • OA: 93.7 OME
      • Postoperative nausea and vomiting:
        • Less frequent in the IVA group
      Safe for Patients. Smart for the Planet.

      Designed with both clinical safety and environmental responsibility in mind: 

      • Preservative-free
      • Povidone-free
      • Not made with DEHP, PVC, or natural rubber latex
      • 24-month shelf life at room temperature
      • Ready-to-use: Overwrap-free
      Explore B. Braun’s Sustainability Initiatives

      Product Specifications

      ProductContainer TypeUsageContent/VolumeSales Unit
      Acetaminophen for Injection 10mg/mL Mini-Plasco® BasicLess than or equal to 10 kg100 mg/10 mL20 x 10 mL
      Acetaminophen for Injection 10mg/mLEcoflac® PlusPediatrics > 10 kg & up to 33 kg500 mg/50 mL10 x 50 mL
      Acetaminophen for Injection 10mg/mLEcoflac® PlusChildren, Adolescents, Adults > 33 kg1,000 mg/100 mL10 x 100 mL 
      The First and Only Intravenous Acetaminophen in Canada Available in Multiple Doses
      One Size Doesn't Fit All

      Dosing Recommendations

      Patient Age/WeightDose given every 4 hours
      		Dose given every 6 hoursMaximum total daily dose of acetaminophen (by any route)
      Children, 2 to 12 years of age12.5 mg/kg15 mg/kg75 mg/kg in 24 hours
      Adults and adolescents weighing 50 kg or less12.5 mg/kg15 mg/kg75 mg/kg (up to 3750 mg) in 24 hours
      Adults and adolescents weighing 50 kg or more and no additional factors for hepatotoxicity650 mg1000 mg 4000 mg in 24 hours

      Indications and Usage

      Acetaminophen for injection is indicated for the short-term management and treatment of 7:

      • Mild to moderate pain
      • Moderate to severe pain with adjunctive opioid analgesics
      • Fever

      Pediatrics (< 2 years of age) 7:

      • Based on the data submitted and reviewed by Health Canada, the safety and efficacy of Acetaminophen for Injection in pediatric patients < 2 years of age has not been established; therefore, Health Canada has not authorized an indication for this age group.

       

      Related Documents

      Acetaminophen for Injection provides fast pain relief and supports efforts to reduce opioid use. Complete the form below, and a B. Braun representative will contact you.

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      1. Marcotte JH, Patel KM, Gaughan JP, Dy J, Kwiatt ME, McClane SJ, Desai RG. Oral Versus Intravenous Acetaminophen within an Enhanced Recovery after Surgery Protocol in Colorectal Surgery. Pain Physician. 2020 Jan;23(1):57-64. PMID: 32013279.
      2. Lu B, Tian AX, Fan ZR, Zhao XW, Jin HZ, Ma JX, Ma XL. Effectiveness of oral vs intravenous acetaminophen on pain management following total joint arthroplasty: A systematic review and meta-analysis. World J Orthop. 2025 Apr 18;16(4):104452. doi: 10.5312/wjo.v16.i4.104452. PMID: 40290608; PMCID: PMC12019136.
      3. Hatt L. The opioid crisis in Canada. Library of Parliament. 2022 Jan 6. Available from: https://lop.parl.ca/sites/PublicWebsite/default/en_CA/ResearchPublications/202123E#a2.2 
      4. Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA. Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery. Br J Anaesth. 2005 May;94(5):642-8. doi: 10.1093/bja/aei109. Epub 2005 Mar 24. PMID: 15790675.
      5. Ameer B, Divoll M, Abernethy DR, Greenblatt DJ, Shargel L. Absolute and relative bioavailability of oral acetaminophen preparations. J Pharm Sci. 1983 Aug;72(8):955-8. doi: 10.1002/jps.2600720832. PMID: 6688635.
      6. WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents. Geneva: World Health Organization; 2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537492/ 
      7. Product Monograph B. Braun Acetaminophen Injection February 2023
      8. Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R. CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022. MMWR Recomm Rep. 2022 Nov 4;71(3):1-95. doi: 10.15585/mmwr.rr7103a1. PMID: 36327391; PMCID: PMC9639433.